Doyle's research is on theoretical foundations for complex tech, bio, med, neuro, and social networks integrating control, communications, computing, and multiscale physics. Layered architectures such as brains integrate high level planning with fast lower level sensing, reflex, and action and facilitate learning, adaptation, augmentation (tools), and teamwork, despite being implemented in energy efficient hardware with sparse, quantized, noisy, delayed, and saturating sensing, communications, computing, and actuation, on time scales from milliseconds to minutes to days. We are developing a mathematical framework that deals with all of these features and constraints in a coherent and rigorous way with broad applications in science and technology.